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Flavonoid biosynthesis : ウィキペディア英語版 | Flavonoid biosynthesis Flavonoids are synthesized by the phenylpropanoid metabolic pathway in which the amino acid phenylalanine is used to produce 4-coumaroyl-CoA. This can be combined with malonyl-CoA to yield the true backbone of flavonoids, a group of compounds called chalcones, which contain two phenyl rings. Conjugate ring-closure of chalcones results in the familiar form of flavonoids, the three-ringed structure of a flavone. The metabolic pathway continues through a series of enzymatic modifications to yield flavanones → dihydroflavonols → anthocyanins. Along this pathway, many products can be formed, including the flavonols, flavan-3-ols, proanthocyanidins (tannins) and a host of other various polyphenolics. Flavanoids can possess chiral carbons. Methods of analysis should take this element into account〔(Methods of analysis and separation of chiral flavonoids. Jaime A. Yáñeza, Preston K. Andrewsb and Neal M. Journal of Chromatography B, Volume 848, Issue 2, 1 April 2007, Pages 159-181 )〕 especially regarding bioactivity or enzyme stereospecificity.〔(A theoretical study of the conformational behavior and electronic structure of taxifolin correlated with the free radical-scavenging activity. Patrick Trouillas, Catherine Fagnère, Roberto Lazzaroni, Claude Calliste, Abdelghafour Marfak and Jean-Luc Duroux, Food Chemistry, Volume 88, Issue 4, December 2004, Pages 571-582 )〕 == Enzymes == The biosynthesis of flavonoids involves several enzymes. * Anthocyanidin reductase * Chalcone isomerase * Dihydrokaempferol 4-reductase * Flavone synthase * Flavonoid 3'-monooxygenase * Flavonol synthase * Flavanone 3-dioxygenase * Flavanone 4-reductase * Leucoanthocyanidin reductase * Leucocyanidin oxygenase * Naringenin-chalcone synthase
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